Innovative Approaches for the Identification of Mitochondria-Cell Signaling Networks in Response to Environmental Stress

Quick Facts

Due DateSeptember 15, 2014 (Monday)
Award AmountUn-Known
Category of Funding ActivityEnvironment
Health
Eligible Applicants
  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public and State controlled institutions of higher education
  • Native American tribal governments (Federally recognized)
  • Public housing authorities/Indian housing authorities
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • For-profit organizations other than small businesses
  • Small businesses
  • Others - Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Program Description

This Funding Opportunity Announcement (FOA) supports the development of technologies and experimental models to more precisely track signaling between the mitochondria and other cellular processes under environmental stress conditions, including mitochondrial-nuclear signaling with respect to epigenetic regulation, DNA damage response, or response to oxidative stress. This FOA uses the R21/R33 Phased Innovation Award mechanism to develop new technologies and experimental models to elucidate mitochondrial-cell signaling. Technologies developed in the R21 phase may include more sensitive reagents for detection of specific reactive oxygen or nitrogen species, enhanced approaches for metabolic flux analysis, and expanded in vitro or experimental models for identifying alterations in signaling pathways in response to environmental stressors. Successful completion of milestones outlined in the R21 phase will enable investigators to be considered for the R33 phase to conduct additional pilot testing and validation of these technologies using environmental stressors to probe bidirectional communication resulting in either altered cellular programming or mitochondrial function or both.

General Information

Funding Opportunity NumberRFA-ES-14-006
Funding Opportunity TitleInnovative Approaches for the Identification of Mitochondria-Cell Signaling Networks in Response to Environmental Stress
Opportunity CategoryEnvironment
Health
Funding Instrument TypeGrant
Category ExplanationNot Available
Number of AwardsNot Available
Cost Sharing or Matching RequirementNo
Posted DateJune 11, 2014 (Wednesday)
Application Due DateSeptember 15, 2014 (Monday)
Application Archive DateOctober 16, 2014 (Thursday)
Total Program Funding$ 3,000,000
Award AmountUn-Known
CFDA Number
  • 93.113 - Environmental Health
  • 000000

Eligible Applicants

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public and State controlled institutions of higher education
  • Native American tribal governments (Federally recognized)
  • Public housing authorities/Indian housing authorities
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • For-profit organizations other than small businesses
  • Small businesses
  • Others - Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Contact Information

Agency NameDepartment of Health and Human Services
Program Information Websitehttp://grants.nih.gov/grants/guide/rfa-files/RFA-ES-14-006.html
ContactOffice: National Institutes of Health
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV

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