Molecular and Cellular Characterization of Screen-Detected Lesions (U01)

Quick Facts

Due DateSeptember 17, 2014 (Wednesday)
Award AmountUp to $ 500,000
Category of Funding ActivityEducation
Health
Eligible Applicants
  • State governments
  • Public and State controlled institutions of higher education
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • For-profit organizations other than small businesses
  • Small businesses
  • Others - Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Program Description

The goal of this Funding Opportunity Announcement (FOA), is to solicit applications from independent, multi-disciplinary teams to undertake a comprehensive molecular and cellular characterization of tumor tissue, cell, and microenvironment components to distinguish screen-detected early lesions from interval and symptom-detected cancers.Individual research teams will pursue one or more aspects of molecular and cellular analysis of one or more of the specified tumor sites (breast, prostate, lung, melanoma, and pancreas).Use of enabling approaches and technologies will be encouraged to determine both the cellular and molecular phenotypes of early lesions, to assess the degree to which the behavior of these lesions is predictable or stochastic, and to allow better predictions of the fate of early lesions.To achieve the goal of a comprehensive characterization of screen-detected lesions, each research team should include cancer researchers and clinicians with multi-disciplinary expertise.The individual research teams funded through this FOA are expected to participate in a collaborative Consortium.In addition to individual studies, a major collaborative effort within the Consortium will be the establishment of an annotated biospecimen repository of screen-detected lesions and interval cancers.Research teams will also be expected to share results freely within the Consortium, and develop trans-Consortium collaborative projects that make use of the combined expertise and technological capabilities present in all of the teams.During the final selection of the teams to be funded through this FOA, NCI will, if possible, attempt to ensure that most of the specified tumor sites are represented.

General Information

Funding Opportunity NumberRFA-CA-14-010
Funding Opportunity TitleMolecular and Cellular Characterization of Screen-Detected Lesions (U01)
Opportunity CategoryEducation
Health
Funding Instrument TypeCooperative Agreement
Category ExplanationNot Available
Number of AwardsNot Available
Cost Sharing or Matching RequirementNo
Posted DateJune 6, 2014 (Friday)
Application Due DateSeptember 17, 2014 (Wednesday)
Application Archive DateOctober 18, 2014 (Saturday)
Total Program Funding$ 4,500,000
Award AmountUp to $ 500,000
CFDA Number
  • 93.393 - Cancer Cause and Prevention Research
  • 93.394 - Cancer Detection and Diagnosis Research
  • 93.396 - Cancer Biology Research
  • 000000

Eligible Applicants

  • State governments
  • Public and State controlled institutions of higher education
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • For-profit organizations other than small businesses
  • Small businesses
  • Others - Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Contact Information

Agency NameDepartment of Health and Human Services
Program Information Websitehttp://grants.nih.gov/grants/guide/rfa-files/RFA-CA-14-010.html
ContactOffice: National Institutes of Health
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV

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