Limited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (UH2/UH3)

Quick Facts

Due DateJanuary 16, 2015 (Friday)
Award AmountUn-Known
Category of Funding ActivityEducation
Health
Income Security and Social Services
Eligible Applicants
  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public and State controlled institutions of higher education
  • Native American tribal governments (Federally recognized)
  • Public housing authorities/Indian housing authorities
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • For-profit organizations other than small businesses
  • Small businesses
  • Others - Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Program Description

The National Center for Advancing Translational Sciences (NCATS) seeks to expand the therapeutics discovery program piloted in 2012 to explore new therapeutic uses for proprietary drug candidates (Agents) across a broad range of human diseases. This innovative program allows investigators to propose new therapeutic uses for Agents from pharmaceutical company partners. A strong application will be supported by scientific evidence that modulation of the Agents target will have a positive impact on the disease/condition. PAR-14-213 encourages X02 pre-applications for the NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules.The X02 pre-application is the first step in the application process for PAR-14-212, PAR-14-210, and PAR-14-211; applicants must read all of the companion FOAs.The X02 pre-applications will be evaluated by outside experts. Investigators whose X02 pre-applications are judged to be the most meritorious will be notified of the opportunity to submit a UH2/UH3 application under this FOA or a UH3 under PAR-14-211 or a UH2/UH3 application under PAR-14-210 in the case of a pediatric indication. The UH2/UH3 is a two stage application. 1. The UH2 (Stage 1) may be used to support milestone-driven preclinical studies to verify target engagement in a disease model and/or Phase 1b clinical trials using the selected Agent in its existing formulation/route of administration to identify the dose or exposure of the Agent in the proposed patient group, and inform patient selection. Support for the UH2 may be requested for a period that may vary from six months up to one year.UH2 projects that have met the scientific milestones and feasibility requirements will be eligible for rapid transition to the second UH3 stage after NIH administrative review. 2. The UH3 (Stage 2) will support milestone-driven Phase 2a trials to demonstrate that the Agent, made available for this program by the pharmaceutical partners, modulates the target and has the potential to yield the desired clinical outcome in the proposed disease population.The project period for the UH3 stage is up to two years.

General Information

Funding Opportunity NumberPAR-14-212
Funding Opportunity TitleLimited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (UH2/UH3)
Opportunity CategoryEducation
Health
Income Security and Social Services
Funding Instrument TypeCooperative Agreement
Category ExplanationNot Available
Number of AwardsNot Available
Cost Sharing or Matching RequirementNo
Posted DateMay 12, 2014 (Monday)
Application Due DateJanuary 16, 2015 (Friday)
Application Archive DateFebruary 16, 2015 (Monday)
Total Program Funding$ 0
Award AmountUn-Known
CFDA Number
  • 93.103 - Food and Drug Administration_Research
  • 93.121 - Oral Diseases and Disorders Research
  • 93.173 - Research Related to Deafness and Communication Disorders
  • 93.242 - Mental Health Research Grants
  • 93.273 - Alcohol Research Programs
  • 93.279 - Drug Abuse and Addiction Research Programs
  • 93.350 - National Center for Advancing Translational Sciences
  • 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders
  • 93.865 - Child Health and Human Development Extramural Research
  • 93.866 - Aging Research
  • 93.867 - Vision Research
  • 000000

Eligible Applicants

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public and State controlled institutions of higher education
  • Native American tribal governments (Federally recognized)
  • Public housing authorities/Indian housing authorities
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • For-profit organizations other than small businesses
  • Small businesses
  • Others - Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Contact Information

Agency NameDepartment of Health and Human Services
Program Information Websitehttp://grants.nih.gov/grants/guide/pa-files/PAR-14-212.html
ContactOffice: National Institutes of Health
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV

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